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Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study.

Postuma RB, Iranzo A, Hu M, Högl B, Boeve BF, Manni R, Oertel WH, Arnulf I, Ferini-Strambi L, Puligheddu M, Antelmi E, Cochen De Cock V, Arnaldi D, Mollenhauer B, Videnovic A, Sonka K, Jung KY, Kunz D, Dauvilliers Y, Provini F, Lewis SJ, Buskova J, Pavlova M, Heidbreder A, Montplaisir JY, Santamaria J, Barber TR, Stefani A, St Louis EK, Terzaghi M, Janzen A, Leu-Semenescu S, Plazzi G, Nobili F, Sixel-Doering F, Dusek P, Bes F, Cortelli P, Ehgoetz Martens K, Gagnon JF, Gaig C, Zucconi M, Trenkwalder C, Gan-Or Z, Lo C, Rolinski M, Mahlknecht P, Holzknecht E, Boeve AR, Teigen LN, Toscano G, Mayer G, Morbelli S, Dawson B, Pelletier A. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019 Mar 1;142(3):744-759. doi: 10.1093/brain/awz030. PMID: 30789229; PMCID: PMC6391615.

The REM sleep behavior disorder screening questionnaire–a new diagnostic instrument.

Stiasny-Kolster K, Mayer G, Schäfer S, Möller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM sleep behavior disorder screening questionnaire–a new diagnostic instrument. Mov Disord. 2007 Dec;22(16):2386-93. doi: 10.1002/mds.21740. PMID: 17894337.

The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder.

Heintz-Buschart A, Pandey U, Wicke T, Sixel-Döring F, Janzen A, Sittig-Wiegand E, Trenkwalder C, Oertel WH, Mollenhauer B, Wilmes P. The nasal and gut microbiome in Parkinson’s disease and idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 2018 Jan;33(1):88-98. doi: 10.1002/mds.27105. Epub 2017 Aug 26. PMID: 28843021; PMCID: PMC5811909.

The Metabolic Pattern of Idiopathic REM Sleep Behavior Disorder Reflects Early-Stage Parkinson Disease.

Meles SK, Renken RJ, Janzen A, Vadasz D, Pagani M, Arnaldi D, Morbelli S, Nobili F, Mayer G, Leenders KL, Oertel WH; REMPET Study Group. The Metabolic Pattern of Idiopathic REM Sleep Behavior Disorder Reflects Early-Stage Parkinson Disease. J Nucl Med. 2018 Sep;59(9):1437-1444. doi: 10.2967/jnumed.117.202242. Epub 2018 Feb 23. PMID: 29476004.

Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson’s Disease

Arnaldi D, Meles SK, Giuliani A, Morbelli S, Renken RJ, Janzen A, Mayer G, Jonsson C, Oertel WH, Nobili F, Leenders KL, Pagani M; REMPET Study Group. Brain Glucose Metabolism Heterogeneity in Idiopathic REM Sleep Behavior Disorder and in Parkinson’s Disease. J Parkinsons Dis. 2019;9(1):229-239. doi: 10.3233/JPD-181468. PMID: 30741687.

Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) – A systematic review on potential biomarkers for neurodegeneration

Heller J, Brcina N, Dogan I, Holtbernd F, Romanzetti S, Schulz JB, Schiefer J, Reetz K. Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) – A systematic review on potential biomarkers for neurodegeneration. Sleep Med Rev. 2017 Aug;34:23-33. doi: 10.1016/j.smrv.2016.06.006. Epub 2016 Jun 25. PMID: 27542516.No Content

The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson’s Disease.

Halsband C, Zapf A, Sixel-Döring F, Trenkwalder C, Mollenhauer B. The REM Sleep Behavior Disorder Screening Questionnaire is not Valid in De Novo Parkinson’s Disease. Mov Disord Clin Pract. 2018 Mar 1;5(2):171-176. doi: 10.1002/mdc3.12591. PMID: 30009211; PMCID: PMC6033034.

Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies

Krohn L, Wu RYJ, Heilbron K, Ruskey JA, Laurent SB, Blauwendraat C, Alam A, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Toft M, Bjørnarå KA, Stefani A, Holzknecht E, Monaca CC, Abril B, Plazzi G, Antelmi E, Ferini-Strambi L, Young P, Heidbreder A, Cochen De Cock V, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Sonka K, Kemlink D, Figorilli M, Puligheddu M, Dijkstra F, Viaene M, Oertel W, Toffoli M, Gigli GL, Valente M, Gagnon JF, Nalls MA, Singleton AB; 23andMe Research Team, Desautels A, Montplaisir JY, Cannon P, Ross OA, Boeve BF, Dupré N, Fon EA, Postuma RB, Pihlstrøm L, Rouleau GA, Gan-Or Z. Fine-Mapping of SNCA in Rapid Eye Movement Sleep Behavior Disorder and Overt Synucleinopathies. Ann Neurol. 2020 Apr;87(4):584-598. doi: 10.1002/ana.25687. Epub 2020 Feb 12. PMID: 31976583; PMCID: PMC8025046.

REM-Schlaf-Verhaltensstörung als prodromales Stadium von α-Synukleinopathien: Klinik, Epidemiologie, Pathophysiologie, Diagnose und Behandlung [REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy].

Oertel WH, Depboylu C, Krenzer M, Vadasz D, Ries V, Sixel-Döring F, Mayer G. REM-Schlaf-Verhaltensstörung als prodromales Stadium von α-Synukleinopathien: Klinik, Epidemiologie, Pathophysiologie, Diagnose und Behandlung [REM sleep behavior disorder as a prodromal stage of α-synucleinopathies: symptoms, epidemiology, pathophysiology, diagnosis and therapy]. Nervenarzt. 2014 Jan;85(1):19-25. German. doi: 10.1007/s00115-013-3891-8. PMID: 24399499.

Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study.

Postuma RB, Montplaisir JY, Pelletier A, Dauvilliers Y, Oertel W, Iranzo A, Ferini-Strambi L, Arnulf I, Hogl B, Manni R, Miyamoto T, Mayer G, Stiasny-Kolster K, Puligheddu M, Ju Y, Jennum P, Sonka K, Santamaria J, Fantini ML, Zucconi M, Leu-Semenescu S, Frauscher B, Terzaghi M, Miyamoto M, Unger MM, Cochen De Cock V, Wolfson C. Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. Neurology. 2012 Jul 31;79(5):428-34. doi: 10.1212/WNL.0b013e31825dd383. Epub 2012 Jun 27. PMID: 22744670; PMCID: PMC3405255.

FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder

Meles SK, Vadasz D, Renken RJ, Sittig-Wiegand E, Mayer G, Depboylu C, Reetz K, Overeem S, Pijpers A, Reesink FE, van Laar T, Heinen L, Teune LK, Höffken H, Luster M, Kesper K, Adriaanse SM, Booij J, Leenders KL, Oertel WH. FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. Mov Disord. 2017 Oct;32(10):1482-1486. doi: 10.1002/mds.27094. Epub 2017 Jul 22. PMID: 28734065; PMCID: PMC5655750.

From bench to bed: putative animal models of REM sleep behavior disorder (RBD)

Krenzer M, Lu J, Mayer G, Oertel W. From bench to bed: putative animal models of REM sleep behavior disorder (RBD). J Neural Transm (Vienna). 2013 Apr;120(4):683-8. doi: 10.1007/s00702-012-0965-x. Epub 2013 Jan 22. PMID: 23338670.

Quantification of tonic and phasic muscle activity in REM sleep behavior disorder.

Mayer G, Kesper K, Ploch T, Canisius S, Penzel T, Oertel W, Stiasny-Kolster K. Quantification of tonic and phasic muscle activity in REM sleep behavior disorder. J Clin Neurophysiol. 2008 Feb;25(1):48-55. doi: 10.1097/WNP.0b013e318162acd7. PMID: 18303560.

Family history of idiopathic REM behavior disorder: a multicenter case-control study.

Dauvilliers Y, Postuma RB, Ferini-Strambi L, Arnulf I, Högl B, Manni R, Miyamoto T, Oertel W, Fantini ML, Puligheddu M, Jennum P, Sonka K, Zucconi M, Leu-Semenescu S, Frauscher B, Terzaghi M, Miyamoto M, Unger M, Desautels A, Wolfson C, Pelletier A, Montplaisir J. Family history of idiopathic REM behavior disorder: a multicenter case-control study. Neurology. 2013 Jun 11;80(24):2233-5. doi: 10.1212/WNL.0b013e318296e967. Epub 2013 May 8. PMID: 23658378; PMCID: PMC3721098.

Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test.

Unger MM, Möller JC, Mankel K, Schmittinger K, Eggert KM, Stamelou M, Stiasny-Kolster K, Bohne K, Bodden M, Mayer G, Oertel WH, Tebbe JJ. Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath test. Mov Disord. 2011 Dec;26(14):2559-63. doi: 10.1002/mds.23933. Epub 2011 Aug 24. PMID: 22147682.

Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study

Frauscher B, Jennum P, Ju YE, Postuma RB, Arnulf I, Cochen De Cock V, Dauvilliers Y, Fantini ML, Ferini-Strambi L, Gabelia D, Iranzo A, Leu-Semenescu S, Mitterling T, Miyamoto M, Miyamoto T, Montplaisir JY, Oertel W, Pelletier A, Prunetti P, Puligheddu M, Santamaria J, Sonka K, Unger M, Wolfson C, Zucconi M, Terzaghi M, Högl B, Mayer G, Manni R. Comorbidity and medication in REM sleep behavior disorder: a multicenter case-control study. Neurology. 2014 Mar 25;82(12):1076-9. doi: 10.1212/WNL.0000000000000247. Epub 2014 Feb 19. PMID: 24553425; PMCID: PMC3962997.

Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic.

Eisensehr I, Linke R, Tatsch K, Kharraz B, Gildehaus JF, Wetter CT, Trenkwalder C, Schwarz J, Noachtar S. Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson’s disease, and controls. Sleep. 2003 Aug 1;26(5):507-12. doi: 10.1093/sleep/26.5.507. PMID: 12938802.

Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regions.

Unger MM, Belke M, Menzler K, Heverhagen JT, Keil B, Stiasny-Kolster K, Rosenow F, Diederich NJ, Mayer G, Möller JC, Oertel WH, Knake S. Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regions. Sleep. 2010 Jun;33(6):767-73. doi: 10.1093/sleep/33.6.767. PMID: 20550017; PMCID: PMC2881532.

Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study.

Postuma RB, Iranzo A, Hogl B, Arnulf I, Ferini-Strambi L, Manni R, Miyamoto T, Oertel W, Dauvilliers Y, Ju YE, Puligheddu M, Sonka K, Pelletier A, Santamaria J, Frauscher B, Leu-Semenescu S, Zucconi M, Terzaghi M, Miyamoto M, Unger MM, Carlander B, Fantini ML, Montplaisir JY. Risk factors for neurodegeneration in idiopathic rapid eye movement sleep behavior disorder: a multicenter study. Ann Neurol. 2015 May;77(5):830-9. doi: 10.1002/ana.24385. Epub 2015 Mar 13. PMID: 25767079; PMCID: PMC5769479.

PPMI study. Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson’s disease.

Mollenhauer B, Caspell-Garcia CJ, Coffey CS, Taylor P, Singleton A, Shaw LM, Trojanowski JQ, Frasier M, Simuni T, Iranzo A, Oertel W, Siderowf A, Weintraub D, Seibyl J, Toga AW, Tanner CM, Kieburtz K, Chahine LM, Marek K, Galasko D; PPMI study. Longitudinal analyses of cerebrospinal fluid α-Synuclein in prodromal and early Parkinson’s disease. Mov Disord. 2019 Sep;34(9):1354-1364. doi: 10.1002/mds.27806. Epub 2019 Jul 30. PMID: 31361367; PMCID: PMC7098385.

Morbidities in rapid eye movement sleep behavior disorder.

Jennum P, Mayer G, Ju YE, Postuma R. Morbidities in rapid eye movement sleep behavior disorder. Sleep Med. 2013 Aug;14(8):782-7. doi: 10.1016/j.sleep.2012.11.002. Epub 2013 Jan 29. PMID: 23375425; PMCID: PMC3979349.

Combination of ‚idiopathic‘ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT.

Stiasny-Kolster K, Doerr Y, Möller JC, Höffken H, Behr TM, Oertel WH, Mayer G. Combination of ‚idiopathic‘ REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECT. Brain. 2005 Jan;128(Pt 1):126-37. doi: 10.1093/brain/awh322. Epub 2004 Nov 17. PMID: 15548552.

Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT.

Unger MM, Möller JC, Stiasny-Kolster K, Mankel K, Berg D, Walter U, Hoeffken H, Mayer G, Oertel WH. Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECT. Mov Disord. 2008 Mar 15;23(4):596-9. doi: 10.1002/mds.21908. PMID: 18175346.

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy–a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.

Schenck CH, Montplaisir JY, Frauscher B, Hogl B, Gagnon JF, Postuma R, Sonka K, Jennum P, Partinen M, Arnulf I, Cochen de Cock V, Dauvilliers Y, Luppi PH, Heidbreder A, Mayer G, Sixel-Döring F, Trenkwalder C, Unger M, Young P, Wing YK, Ferini-Strambi L, Ferri R, Plazzi G, Zucconi M, Inoue Y, Iranzo A, Santamaria J, Bassetti C, Möller JC, Boeve BF, Lai YY, Pavlova M, Saper C, Schmidt P, Siegel JM, Singer C, St Louis E, Videnovic A, Oertel W. Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy–a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group. Sleep Med. 2013 Aug;14(8):795-806. doi: 10.1016/j.sleep.2013.02.016. Epub 2013 Jul 22.

Unimpaired postprandial pancreatic polypeptide secretion in Parkinson’s disease and REM sleep behavior disorder.

Unger MM, Ekman R, Björklund AK, Karlsson G, Andersson C, Mankel K, Bohne K, Tebbe JJ, Stiasny-Kolster K, Möller JC, Mayer G, Kann PH, Oertel WH. Unimpaired postprandial pancreatic polypeptide secretion in Parkinson’s disease and REM sleep behavior disorder. Mov Disord. 2013 Apr;28(4):529-33. doi: 10.1002/mds.25246. Epub 2012 Dec 12. PMID: 23239509.

Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder.

Rupprecht S, Walther B, Gudziol H, Steenbeck J, Freesmeyer M, Witte OW, Günther A, Schwab M. Clinical markers of early nigrostriatal neurodegeneration in idiopathic rapid eye movement sleep behavior disorder. Sleep Med. 2013 Nov;14(11):1064-70. doi: 10.1016/j.sleep.2013.06.008. Epub 2013 Aug 13. PMID: 23948220.

A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study.

Postuma RB, Arnulf I, Hogl B, Iranzo A, Miyamoto T, Dauvilliers Y, Oertel W, Ju YE, Puligheddu M, Jennum P, Pelletier A, Wolfson C, Leu-Semenescu S, Frauscher B, Miyamoto M, Cochen De Cock V, Unger MM, Stiasny-Kolster K, Fantini ML, Montplaisir JY. A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study. Mov Disord. 2012 Jun;27(7):913-6. doi: 10.1002/mds.25037. Epub 2012 May 30. PMID: 22729987; PMCID: PMC4043389.

Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease?

Unger MM, Möller JC, Mankel K, Eggert KM, Bohne K, Bodden M, Stiasny-Kolster K, Kann PH, Mayer G, Tebbe JJ, Oertel WH. Postprandial ghrelin response is reduced in patients with Parkinson’s disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson’s disease? J Neurol. 2011 Jun;258(6):982-90. doi: 10.1007/s00415-010-5864-1. Epub 2010 Dec 24. PMID: 21181542.

The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder.

Gan-Or Z, Montplaisir JY, Ross JP, Poirier J, Warby SC, Arnulf I, Strong S, Dauvilliers Y, Leblond CS, Hu MTM, Högl B, Stefani A, Monaca CC, De Cock VC, Boivin M, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Barber TR, Evetts SG, Rolinski M, Dion PA, Desautels A, Gagnon JF, Dupré N, Postuma RB, Rouleau GA. The dementia-associated APOE ε4 allele is not associated with rapid eye movement sleep behavior disorder. Neurobiol Aging. 2017 Jan;49:218.e13-218.e15. doi: 10.1016/j.neurobiolaging.2016.10.002. Epub 2016 Oct 13. PMID: 27814994.

Ictal SPECT in patients with rapid eye movement sleep behaviour disorder.

Mayer G, Bitterlich M, Kuwert T, Ritt P, Stefan H. Ictal SPECT in patients with rapid eye movement sleep behaviour disorder. Brain. 2015 May;138(Pt 5):1263-70. doi: 10.1093/brain/awv042. Epub 2015 Mar 1. PMID: 25732183; PMCID: PMC5963405.

Comparison of computerized methods for rapid eye movement sleep without atonia detection.

Cesari M, Christensen JAE, Kempfner L, Olesen AN, Mayer G, Kesper K, Oertel WH, Sixel-Döring F, Trenkwalder C, Sorensen HBD, Jennum P. Comparison of computerized methods for rapid eye movement sleep without atonia detection. Sleep. 2018 Oct 1;41(10). doi: 10.1093/sleep/zsy133. PMID: 30011023.

Dysautonomia in prodromal α-synucleinopathy: peripheral versus central autonomic degeneration.

Dahms C, Guenther A, Schwab M, Schultze T, Nowack S, Hoyer D, Ehrhardt J, Witte OW, Mayer G, Rupprecht S. Dysautonomia in prodromal α-synucleinopathy: peripheral versus central autonomic degeneration. Eur J Neurol. 2016 May;23(5):878-90. doi: 10.1111/ene.12957. Epub 2016 Feb 4. PMID: 26842960.

Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder

Stiasny-Kolster K, Clever SC, Möller JC, Oertel WH, Mayer G. Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorder. Brain. 2007 Feb;130(Pt 2):442-9. doi: 10.1093/brain/awl343. PMID: 17235125.

Transcranial midbrain sonography in narcoleptic subjects with and without concomitant REM sleep behaviour disorder.

Unger MM, Möller JC, Ohletz T, Stiasny-Kolster K, Oertel WH, Mayer G. Transcranial midbrain sonography in narcoleptic subjects with and without concomitant REM sleep behaviour disorder. J Neurol. 2009 Jun;256(6):874-7. doi: 10.1007/s00415-009-5032-7. Epub 2009 Feb 28. PMID: 19252799.

Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder.

Han X, Wu P, Alberts I, Zhou H, Yu H, Bargiotas P, Yakushev I, Wang J, Höglinger G, Förster S, Bassetti C, Oertel W, Schwaiger M, Huang SC, Cumming P, Rominger A, Jiang J, Zuo C, Shi K. Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder. Neuroimage Clin. 2020;27:102294. doi: 10.1016/j.nicl.2020.102294. Epub 2020 May 26. PMID: 32570206; PMCID: PMC7322340.

Dopamine transporter imaging predicts clinically-defined α-synucleinopathy in REM sleep behavior disorder.

Chahine LM, Brumm MC, Caspell-Garcia C, Oertel W, Mollenhauer B, Amara A, Fernandez-Arcos A, Tolosa E, Simonet C, Hogl B, Videnovic A, Hutten SJ, Tanner C, Weintraub D, Burghardt E, Coffey C, Cho HR, Kieburtz K, Poston KL, Merchant K, Galasko D, Foroud T, Siderowf A, Marek K, Simuni T, Iranzo A. Dopamine transporter imaging predicts clinically-defined α-synucleinopathy in REM sleep behavior disorder. Ann Clin Transl Neurol. 2021 Jan;8(1):201-212. doi: 10.1002/acn3.51269. Epub 2020 Dec 15. PMID: 33321002; PMCID: PMC7818144.

PPMI Sleep Working Group. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder.

Chahine LM, Iranzo A, Fernández-Arcos A, Simuni T, Seedorff N, Caspell-Garcia C, Amara AW, Comella C, Högl B, Hamilton J, Marek K, Mayer G, Mollenhauer B, Postuma R, Tolosa E, Trenkwalder C, Videnovic A, Oertel W; PPMI Sleep Working Group. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinsons Dis. 2019 Jan 29;5:2. doi: 10.1038/s41531-018-0073-1. PMID: 30701189; PMCID: PMC6351563.

Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson’s disease and controls.

Eisensehr I, Linke R, Noachtar S, Schwarz J, Gildehaus FJ, Tatsch K. Reduced striatal dopamine transporters in idiopathic rapid eye movement sleep behaviour disorder. Comparison with Parkinson’s disease and controls. Brain. 2000 Jun;123 ( Pt 6):1155-60. doi: 10.1093/brain/123.6.1155. PMID: 10825354.

Identifying prodromal Parkinson’s disease: pre-motor disorders in Parkinson’s disease.

Postuma RB, Aarsland D, Barone P, Burn DJ, Hawkes CH, Oertel W, Ziemssen T. Identifying prodromal Parkinson’s disease: pre-motor disorders in Parkinson’s disease. Mov Disord. 2012 Apr 15;27(5):617-26. doi: 10.1002/mds.24996. PMID: 22508280.

Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility.

Donadio V, Doppler K, Incensi A, Kuzkina A, Janzen A, Mayer G, Volkmann J, Rizzo G, Antelmi E, Plazzi G, Sommer C, Liguori R, Oertel WH. Abnormal α-synuclein deposits in skin nerves: intra- and inter-laboratory reproducibility. Eur J Neurol. 2019 Oct;26(10):1245-1251. doi: 10.1111/ene.13939. Epub 2019 Aug 2. PMID: 30770596.

LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder.

Ouled Amar Bencheikh B, Ruskey JA, Arnulf I, Dauvilliers Y, Monaca CC, De Cock VC, Gagnon JF, Spiegelman D, Hu MTM, Högl B, Stefani A, Ferini-Strambi L, Plazzi G, Antelmi E, Young P, Heidbreder A, Mollenhauer B, Sixel-Döring F, Trenkwalder C, Oertel W, Montplaisir JY, Postuma RB, Rouleau GA, Gan-Or Z. LRRK2 protective haplotype and full sequencing study in REM sleep behavior disorder. Parkinsonism Relat Disord. 2018 Jul;52:98-101. doi: 10.1016/j.parkreldis.2018.03.019. Epub 2018 Mar 21. PMID: 29576439.

Progression Markers Initiative. Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease.

Amara AW, Chahine LM, Caspell-Garcia C, Long JD, Coffey C, Högl B, Videnovic A, Iranzo A, Mayer G, Foldvary-Schaefer N, Postuma R, Oertel W, Lasch S, Marek K, Simuni T; Parkinson’s Progression Markers Initiative. Longitudinal assessment of excessive daytime sleepiness in early Parkinson’s disease. J Neurol Neurosurg Psychiatry. 2017 Aug;88(8):653-662. doi: 10.1136/jnnp-2016-315023. Epub 2017 May 29. PMID: 28554959; PMCID: PMC7282477.

Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder.

Chahine LM, Xie SX, Simuni T, Tran B, Postuma R, Amara A, Oertel WH, Iranzo A, Scordia C, Fullard M, Linder C, Purri R, Darin A, Rennert L, Videnovic A, Del Riva P, Weintraub D. Longitudinal changes in cognition in early Parkinson’s disease patients with REM sleep behavior disorder. Parkinsonism Relat Disord. 2016 Jun;27:102-6. doi: 10.1016/j.parkreldis.2016.03.006. Epub 2016 Mar 12. PMID: 27010070; PMCID: PMC5031362.

Correlates of excessive daytime sleepiness in de novo Parkinson’s disease: A case control study.

Simuni T, Caspell-Garcia C, Coffey C, Chahine LM, Lasch S, Oertel WH, Mayer G, Högl B, Postuma R, Videnovic A, Amara AW, Marek K; PPMI Sleep Working group on behalf of the PPMI Investigators. Correlates of excessive daytime sleepiness in de novo Parkinson’s disease: A case control study. Mov Disord. 2015 Sep;30(10):1371-81. doi: 10.1002/mds.26248. Epub 2015 Jun 11. PMID: 26095202; PMCID: PMC4822999.

Four-Year Follow-up of [18 F]Fluorodeoxyglucose Positron Emission Tomography-Based Parkinson’s Disease-Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression.

Kogan RV, Janzen A, Meles SK, Sittig E, Renken RJ, Gurvits V, Mayer G, Leenders KL, Oertel WH; REMPET Working Group. Four-Year Follow-up of [18 F]Fluorodeoxyglucose Positron Emission Tomography-Based Parkinson’s Disease-Related Pattern Expression in 20 Patients with Isolated Rapid Eye Movement Sleep Behavior Disorder Shows Prodromal Progression. Mov Disord. 2021 Jan;36(1):230-235. doi: 10.1002/mds.28260. Epub 2020 Sep 10. PMID: 32909650; PMCID: PMC7891341.

Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson’s disease

Lahut S, Gispert S, Ömür Ö, Depboylu C, Seidel K, Domínguez-Bautista JA, Brehm N, Tireli H, Hackmann K, Pirkevi C, Leube B, Ries V, Reim K, Brose N, den Dunnen WF, Johnson M, Wolf Z, Schindewolf M, Schrempf W, Reetz K, Young P, Vadasz D, Frangakis AS, Schröck E, Steinmetz H, Jendrach M, Rüb U, Başak AN, Oertel W, Auburger G. Blood RNA biomarkers in prodromal PARK4 and rapid eye movement sleep behavior disorder show role of complexin 1 loss for risk of Parkinson’s disease. Dis Model Mech. 2017 May 1;10(5):619-631. doi: 10.1242/dmm.028035. Epub 2017 Jan 20. PMID: 28108469; PMCID: PMC5451169.

Autonomic symptoms in idiopathic REM behavior disorder: a multicentre case-control study

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